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KMID : 0043320050280121337
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Archives of Pharmacal Research
2005 Volume.28 No. 12 p.1337 ~ p.1340
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Induction of Neurite Outgrowth by (-)-(7R, 8S)-Dihydrodehydrodiconiferyl Alcohol from PC12 Cells
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Shin Jung-Soo
Kim Yu-Mi
Hong Seong-Soo
Kang Ho-Sang
Yang Yoo-Jung
Lee Don-Koo
Hwang Bang-Yeon
Ro Jai-Seup
Lee Myung-Koo
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Abstract
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A lignan derivative, (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol (DHDA), was isolated from Kalopanax septemlobus L. and was observed to have neuritogenic activity. DHDA at 50 M caused a marked induction of neurite outgrowth and an enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. However, it did not exhibit any neurotrophic action. At 50 M, DHDA enhanced NGF-induced neurite-bearing activity. This activity was partially blocked by the mitogen-activated protein kinase (MAPK) inhibitor PD98059 and by GF109203X, a protein kinase C (PKC) inhibitor. These results suggest that DHDA can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.
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KEYWORD
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(-)-(7R, 8S)-Dihydrodehydrodiconiferyl alcohol, Kalopanax septemlobus, Neurite outgrowth, PC12 cells
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